Clinically, there are three major syndromes, behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA), whilst pathologically, the majority of cases have inclusions containing either tau (FTLD-tau) or TDP-43 (FTLD-TDP). This evidence concerns the gene MAPT and behavioral variant of frontotemporal dementia.