The striking glandular overexpression of CXCL12 and CXCL13 in pSS patients might contribute to the preferential migration of CXCR4 and CXCR5 expressing CD27+ memory B cells into the inflamed salivary glands, resulting in lower numbers of circulating CD27+ memory cells [24]. The gene discussed is CXCR4; the disease is peeling skin syndrome.