CXCR4 and peeling skin syndrome: Furthermore, CXCL12–CXCR4 and CXCL13–CXCR5 interactions have been widely suggested to be involved in B-cell disturbance during pSS and may be closely associated with the whole inflammatory process, the development of ectopic GC-like structures as well as the peripheral B-cell abnormalities [25].