Investigators in a recent study reported that IL-29 induces the secretion of chemokines IFN-γ-inducible protein 10, monokine induced by IFN-γ and IL-8 in peripheral blood mononuclear cells (PBMCs) [11,12] in patients with systemic lupus erythematosus (SLE), implying its involvement in SLE pathogenesis. This evidence concerns the gene CXCL8 and systemic lupus erythematosus.