In this regard, it is noteworthy that TLR antagonists such as IRS-954 (TLR7 and TLR9 antagonist) [42,43] and IMO-8400 (TLR7, TLR8 and TLR9 antagonist) are currently undergoing clinical trials in SLE. Here, TLR8 is linked to systemic lupus erythematosus.