Moreover, T3-induced hyperthyroidism stimulated oxidative damage in ratmuscle [40], whereas in hepatic stellatecells (HSCs) isolated from rats treated with thioacetamide (TAA), triiodothyronine(T3) and L-thyroxine (T4) enhancedactivation of HSC and their transdifferentiation in myofibroblasts throughactivation of Rho. This evidence concerns the gene RHO and hyperthyroidism.