INS and neoplasm: The NP core was composed of insulin multimethacrylate with a targeting peptide, cyclic RGD, covalently attached to the NPs via PEG-400 and revealed decreasing drug concentrations over time in the heart, lung, kidney, and plasma and accumulating drug concentrations in the liver, spleen, and tumor due to drug-receptor interaction as particle largely composed of carbohydrate, the insulin derivative, that is, insulin multimethacrylate (IMMA).