A study by Castelli et al. [23] provided similar results, but the results were not confirmed in a study by Silvestre et al. [24] In the study by Castelli et al. [23], the authors compared CRP concentrations in 255 patients (111 septic, 49 trauma, 45 with and 50 without systemic inflammatory response syndrome [SIRS]) observed for a total of 1826 days [23]. The gene discussed is CRP; the disease is systemic inflammatory response syndrome.