Seligman et al. [36] also reported no difference in admission CRP concentrations between survivors and nonsurvivors in patients with VAP (P = 0.77), but in a logistic regression model, a decrease in CRP between day 4 and day 0 was associated with a favorable outcome (odds ratio 7.4 (95% CI: 1.58–34.73). The gene discussed is CRP; the disease is ventilator-associated pneumonia.