MBTPS1 and neoplasm: Furthermore, the role of S1P in tumor-induced angiogenesis and lymphangiogenesis needs to be investigated more precisely in this context; since S1P is provided not only from blood and endothelial cells, but also from tumors [199], and the contribution of S1P in the angiogenesis and lymphangiogenesis induced by tumors may be different from that which occurs in the normal vascular development processes (Figure 2B).