IFNG and type 1 diabetes mellitus: Recently—in addition to the alternative activation of macrophages in T1DM [62]—hypopresponsivity of macrophages to IFN-γ has been demonstrated in the NOD mouse animal model [63], and it is possible that apoptotic cell clearance itself inhibited the macrophage responses to a major macrophage activator providing priming signal IFN-γ [64] and its downstream signaling (JAK-STAT1—Janus kinase and signal transducer and activator of transcription 1-path).