CTLA4 and type 1 diabetes mellitus: By using the chromatin immunoprecipitation linked to microarray (ChIP-chip) approach to compare genome wide histone H3 lysine 9 dimethylation (H3K9me2) patterns in peripheral blood lymphocytes and monocytes from T1DM patients, the T1DM candidate gene CTLA4 has been displayed higher H3K9me2 at the promoter region yet standing as an example of interface between genetic and epigenetic information in T1DM [126].