For example, the splicing profile of ABCC1, Mdm2, and fibronectin transcripts has been used to distinguish normal ovary from epithelial ovarian cancer [127], whereas altered splicing of MED24, MFI2, SRRT, CD44, and CLK1 has been associated with metastatic phenotype in breast cancer and poor prognosis in patients [128]. The gene discussed is CD44; the disease is breast carcinoma.