BCL2L11 and melanoma: For example, treatment of melanoma cells, harbouring B-Raf (V600E) mutation with B-RAF inhibitors, determines over-expression of SRSF6 that in turn regulates alternative splicing of the Bim gene, a member of the Bcl-2 family, promoting the production of the proapoptotic short isoform BimS [177, 178].