The effects of tesaglitazar on glucose and lipid metabolism in the obese Zucker rat [16] have generally proven to be predictive of effects in patients with type 2 diabetes [30] and obese/insulin resistant subjects [28, 29, 40], with improvements in glucose tolerance, lipid tolerance, insulin sensitivity, and meal induced FFA lowering, as well as decreased plasma TG levels and decreased apoCIII levels seen in both humans and rodents. The gene discussed is INS; the disease is type 2 diabetes mellitus.