Furthermore, treatment of endotoxin and interferon-γ to C2C12 myotubes has been shown to mimic several signaling events we observed in muscle during severe cachexia including the reduction in phosphorylated mTOR and p70S6k and the increase in phosphorylated raptor and activation of AMPK (Frost et al., 2009). Here, RPS6KB1 is linked to Cachexia.