In addition we have reported a marked reduction in voluntary exercise in the cachectic ApcMin/+ mouse (Carson and Baltgalvis, 2010; Puppa et al., 2011b); however, forced treadmill training during IL-6 induced cachexia in the ApcMin/+ mouse is able to increase muscle oxidative capacity and prevent weight loss (Puppa et al., 2011b). The gene discussed is IL6; the disease is Cachexia.