Other preliminary data from the Sinclair laboratory has also shown that a number of other cellular proteins with potent anti-apoptotic function are up-regulated in latently infected CD34+ cells (J.S. unpublished data) and this includes the PEA-15 protein, further supporting a model by which induction of PEA-15 during latent infection, at least in part, protects latently infected cells from pro-death signals. The gene discussed is PEA15; the disease is disease arising from reactivation of latent virus.