Treatment of stroke with Niaspan significantly increases Angiopoietin-1 (Ang1) expression in ischemic brain which promotes vascular stabilization [18] and decreases brain hemorrhage and BBB leakage in T1DM rats [16,19] and regulates angiogenesis as well as improves functional outcome after stroke [15,16]. Here, ANGPT1 is linked to intracranial hemorrhage.