CTNND1 and cancer: The significance of the membrane versus cytosolic distribution of p120 is underscored by studies showing that altered distribution of p120 in human cancers correlated with tumorigenicity, anoikis resistance, poor patient outcome and aggressive metastatic disease (Smalley-Freed et al., 2011; Schackmann et al., 2011; Bellovin et al., 2005).