On the other hand, M2 cells produce interleukin 10 (IL-10) and transforming growth factor β (TGF- β) leading to a suppression of general antitumour immune responses, promoting tumour neoangiogenesis by the secretion of pro-angiogenic factors and defining the invasive microenvironment to facilitate tumour metastasis and dissemination 23. Here, IL10 is linked to neoplasm.