CD4 and HIV infectious disease: Finally, among HIV-positive individuals in the Study of Fat Redistribution and Metabolic change in HIV Infection (FRAM), mortality rates were 2.3 times higher than in HIV-negative controls in individuals with a CD4 count of greater than 350 cells/mm3, but 6.3 times higher in those with a CD4 count of less than 350 cells/mm3[26].