In autologous cultures of primary ALCL and DLBCL cells, PD-L1 blockade enhanced the secretion of the inflammatory cytokines IFN-γ, granulocyte macrophage colony-stimulating factor, IL-1, IL-6, IL-8, IL-13, TNF-α, and macrophage inflammatory protein-1α. Here, CD274 is linked to diffuse large B-cell lymphoma.