A higher expression of PD-L1 was found in the majority of different hematological malignant cells, including primary mediastinal large B-cell lymphoma, T-cell/histiocyte-rich B-cell lymphoma, EBV-positive and EBV-negative PTLD, EBV-associated diffuse large B-cell lymphoma (DLBCL), plasmablastic lymphoma, extranodal NK/T-cell lymphoma, Burkitt’s lymphoma, HHV8-associated Kaposi sarcoma, B-cell leukemia, CML, AML cells, as well as in ATL cells in some patients [37,38,40,41,44,45]. This evidence concerns the gene CD274 and acute myeloid leukemia.