Interestingly, a significant number of these proteins had previously been reported to be involved in HCV/HCC disease progression For example, proteins identified in this study like moesin (MSN) (Figure 2A), retinol-binding protein (RBP4), and transgelin (TAGL) (Figure 2B) have been involved in viral induced HCC. Here, PGLYRP2 is linked to hepatocellular carcinoma.