On the contrary, in CLL cases with a mutated TP53 status, CDKN1A expression levels of Nutlin-3 treated and untreated samples barely reached a significant difference (0.042 versus 0.0083, p = 0.043) and, in a similar manner, failed to reach a significant difference for BAX and PUMA (0.0164 versus 0.0354, p = 0.103, BAX; 0.0033 versus 0.0049, p = 0.947, PUMA). This evidence concerns the gene CDKN1A and B-cell chronic lymphocytic leukemia.