As shown in Figure 2A, CLL cases with an unmutated TP53 status had a marked induction upon Nutlin-3 exposure for all the three genes (0.0031 versus 0.0318, CDKN1A; 0.0155 versus 0.0641, BAX; 0.0047 versus 0.0274, PUMA; p < 0.001 for all the comparisons). This evidence concerns the gene CDKN1A and B-cell chronic lymphocytic leukemia.