Aside from TKIs, it is well known that the humanized monoclonal antibody bevacizumab also targets VEGF signaling and therefore prevents binding of VEGF to its receptors, and it has also been approved for the treatment of renal cell, colorectal, breast, and non-small-cell lung cancer (NSCLC) [49]. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.