Sep15/SelM associates with the UDP-glucose: glycoprotein glucosyltransferase (UGTR), a complex responsible for maintaining proper protein folding in the endoplasmic reticulum and one study has shown that the expression of SelM is upregulated in Dermacenter variabilis infected with Anaplasma marginale, and infection levels in tick guts were reduced after SelM knockdown [16]. Here, SELENOM is linked to infection.