Protein profiles for targets such as IL1α and SHKBP1 were significantly different between healthy individuals and each of the primary tumor (PT), lymph node metastasis (LNM), and liver metastasis (LM) patients whereas protein profiles for MAML3 were unique for the classification of LM patients, XIAP for the classification of LNM patients, and EGR3 for PT patients. The gene discussed is SHKBP1; the disease is lymphangioma.