Although we cannot exclude that IR/IGF-IR signaling pathways may affect other important factors, the combination of previous reports from our and other groups [17,19,20] with the present results support a close interplay between E-cadherin, its glycosylation with bisecting GlcNAc N-glycans and IR/IGF-IR signaling in the process of tumour cell invasion. Here, IGF1R is linked to neoplasm.