We here propose that E-cadherin induces the expression of bisecting GlcNAc N-glycans in the absence (switch-off) of IR/IGF-IR signaling, which in turn will contribute to the stabilization of E-cadherin at the cell membrane, ensuring an epithelial-like phenotype, ultimatly promoting tumor suppression [17,36]. Here, CDH1 is linked to neoplasm.