MGAT5 and neoplasm: We have shown that during the acquisition of the malignant phenotype, E-cadherin suffered an increased modification with β1,6 GlcNAc branched N-glycans, catalyzed by N-acetylglucosaminyltransferase V (GnT-V) [18,19], that was further demonstrated to induce a destabilization of E-cadherin-mediated cell-cell adhesion (adherens junction) with consequences to tumor progression [17].