Our study has demonstrated the following in HCC: (i) LC3 expression was significantly associated with longer OS and TTR regardless of tumor stage and liver function; (ii) in particular, LC3 expression was correlated with longer survival in advanced TNM stages (III) and Edmondson–Steiner grades (III, IV); and (iii) ER stress-related proteins were not significantly correlated with autophagy-related proteins. Here, MAP1LC3A is linked to hepatocellular carcinoma.