For example, for TLR4 896 A>G association with malaria, the combined ORG showed that the probability of having malaria might be 31% higher for subjects having higher mutational load relative to those with lower mutational load (subjects who are homozygous for G allele have the highest mutational load, those homozygous for A allele have the lowest, and heterozygous have an intermediate level). The gene discussed is TLR4; the disease is malaria.