IGHE and allergic disease: They also suggest that CSR DNA–protein and/or protein–protein complexes can be destabilized by naturally occurring molecules, leading to inhibition of CSR, thereby providing a basis for the identification of synthetic small molecule compounds, such as those that disrupt DNA–protein and/or protein–protein interactions involving 14-3-3 [26], [73], or biologics that can effectively inhibit unwanted CSR, such as CSR underlying the generation of IgG and IgA autoantibodies in autoimmunity and atopic IgE antibodies in allergies and asthma.