They also suggest that CSR DNA–protein and/or protein–protein complexes can be destabilized by naturally occurring molecules, leading to inhibition of CSR, thereby providing a basis for the identification of synthetic small molecule compounds, such as those that disrupt DNA–protein and/or protein–protein interactions involving 14-3-3 [26], [73], or biologics that can effectively inhibit unwanted CSR, such as CSR underlying the generation of IgG and IgA autoantibodies in autoimmunity and atopic IgE antibodies in allergies and asthma. This evidence concerns the gene IGHE and asthma.