Thus, our findings suggest that 14-3-3 adaptors play important scaffold functions and nucleate the assembly of multiple CSR factors on S regions and that small molecule compounds that specifically disrupt their interactions can be used to inhibit unwanted CSR, such as CSR underlying the generation of IgG and IgA autoantibodies in autoimmunity and atopic IgE antibodies in allergies and asthma. Here, IGHE is linked to Autoimmunity.