Systemic phosphorodiamidate morpholino oligomer (Eteplirsen, AVI-4658) treatment trial. To elucidate whether the exon skipping therapy and the dystrophin restoration induced by eteplirsen influenced the serum level of the dystromirs, we quantified miR-1, miR-206, miR-31, miR-133a and miR-133b in serum samples taken at baseline (pre-treatment samples) and at week 12 (post-treatment samples) in 12 DMD patients included in the systemic antisense oligomer eteplirsen phase II clinical trial [19]. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.