Our results suggest a role of polymorphism rs1229984 in ADH1B in colorectal carcinogenesis but have failed to show such association for polymorphism rs886205 in ALDH2. Although our findings require validation in other independent population, further characterization of ADH1B and ALDH2 polymorphisms may provide new insights into their contribution to incidence and progression of CRC. Here, ADH1B is linked to colorectal carcinoma.