Our observation that both the GBM tumor and normal brain overexpress transcripts that are associated with the MRCC I is also in agreement with the recent observation that depletion of the insulin-like growth factor 2 mRNA-binding protein 2, which is known to interact with the transcripts that encode the MRCC I, reduces oxygen consumption by and impairs proliferation of GBM cell lines [56]. This evidence concerns the gene IGF2 and glioblastoma.