GPT and viral infectious disease: Based on the experimental data and previous researches on the dynamics of virus infection model [3, 10, 12, 13, 15, 16, 20–22], this paper introduces two mathematical models to model, simulate, and analyze the dynamics of the evolutions of patients' mean serum HBV DNA and ALT levels and make long-term prediction for the complete-response patients and the poor-response patients for ADV monotherapy and TCM + ADV combination therapy.