The process involves cytokines first mediating insulin signaling mechanisms in adipocytes, muscles, and the liver to increase the occurrence of insulin resistance [11], before disabling liver X receptors (LXRs) causing an increase in the accumulation of cholesterol, thus stimulating hepatic production and secretion of inflammatory markers, including C-reactive protein, plasminogen inhibitor-1, serum amyloid-A, α1-acid glycoprotein, and haptoglobin [12]. The gene discussed is CRP; the disease is Insulin resistance.