CD28 and myeloid sarcoma: CD46 has also been related to T cells: it is known that CD3/CD46 costimulation promotes T-cell proliferation with a potency comparable with that of CD28 [49], and the importance of CD46 in the regulation of the immune response through the induction of Tr1 cells and IL-10 production has been highlighted [50]; as the role of regulatory T cells in patients with MS has been previously demonstrated by various groups [51, 52], an alteration in CD46 in patients with MS could lead to further damage and inflammation [50].