Compared with WT LRRK2, the familial PD mutations R1441C, Y1699C and G2019S do not significantly alter the interaction of LRRK2 with Dnm1 (Fig. 1H), Mfn1 (Fig. 1I) or OPA1 (Supplementary Material, Fig. S1B). This evidence concerns the gene MFN1 and Parkinson disease.