In fact, AMPK plays an important role in the regulation of a variety of pathways implicated in cell tumor progression [108,109], such as p53, fatty acid synthase (FASN) and the mechanistic target of rapamycin (mTOR), which controls cell survival and regulation of metabolism [110,111] and it is an important signaling in cancer development, including CRC. The gene discussed is FASN; the disease is cancer.