Dysfunctions of cAMP-sensing AKAP complexes seem to contribute to the progression of a wide variety of diseases, including chronic heart failure, cardiac arrhythmia, Alzheimer’s dementia, HIV infection, diabetes mellitus and cancer [17,18,19,20,21], hence, current research intends to target the spatio-temporal cAMP-responsive complexes to provide novel therapeutical interventions [5,11,12,17,22]. The gene discussed is AKAP1; the disease is congestive heart failure.