Currently, NVP-BKM120 is in a Phase I study with the EGFR inhibitor gefitinib in patients with advanced NSCLC particularly enriched with patients harboring alterations of the PI3K pathway and overexpress EGFR [88] and also in a Phase I/II trial with the EGFR inhibitor erlotinib in patients previously sensitive to erlotinib [89]. Here, PIK3CA is linked to non-small cell lung carcinoma.