Preclinical data suggest that everolimus and the EGFR inhibitor erlotinib have synergistic effect in atypical bronchial carcinoids (AC) and large cell neuroendocrine lung carcinomas (LCNEC), indicating the clinical importance of EGFR and mTOR as therapeutic targets in bronchial neuroendocrine tumors [159]. The gene discussed is EGFR; the disease is large cell neuroendocrine carcinoma.