Although the tumor size in rat brain tissue after one week of treatment with CPT-loaded MPEG-PCL-Tat was similar to that in untreated rats, the tumor size after two weeks of treatment with the CPT-loaded MPEG-PCL-Tat was about 4.5 times smaller than in untreated rats (Figure 3f), indicating that CPT-loaded MPEG-PCL-Tat was markedly suppressed tumor growth. This evidence concerns the gene TAT and neoplasm.