Interestingly, additional mutation of the K-ras oncogene concomitantly with LKB1 deletion in lung is able to drive adenocarcinoma formation in this organ, raising the possibility that both deletion of LKB1 and constitutive activation of K-ras in pancreatic epithelium could also be responsible for adenocarcinoma development [51]. This evidence concerns the gene STK11 and adenocarcinoma.