The high-mobility group A2 (HMGA2) protein, a non-histone chromatin factor important for mesenchymal differentiation, is overexpressed in pancreatic carcinoma [99] and was proposed to maintain a mesenchymal state of advanced pancreatic carcinoma cells by activating the Snail promoter [100]. Here, SNAI1 is linked to exocrine pancreatic carcinoma.