They suggest that the precise role of palladin in PC has yet to be defined while, as mentioned, PALLD is associated with a rare form of familial PC where palladin was identified as being overexpressed in samples of sporadic PC as well as in tumor-derived cell lines [40], results which were challenged in a subsequent investigation that utilized immunohistochemical (IHC) screenings of the pancreas tumor array [42]. Here, PALLD is linked to pancreatic neoplasm.