Their study disclosed that the loss of heterozygosity at the BRCA1 locus “...occurs in pancreatic cancers of germline BRCA1 mutation carriers, acting as a ‘second-hit’ event contributing to pancreatic tumorigenesis.” They concluded that BRCA1 germline mutations may be considered for PC screening. The gene discussed is BRCA1; the disease is familial pancreatic carcinoma.