PALLD and pachyonychia congenita: This subject is reviewed by Klein et al. [41] who indicate that Pogue-Geile et al. “...implicated an oncogenic function for palladin after finding overexpression of PALLD mRNA in pancreatic cancer tissues.” However, Klein et al. note that since the Pogue-Geile et al. paper was published, subsequent investigations failed to find evidence linking palladin to familial PC.