Supporting the notion that constitutive NF-κB activity indeed protects cancer cells from chemotherapy-induced apoptosis, several studies demonstrated that NF-κB inhibition through expression of the IκBα super-repressor mutant or pharmacological NF-κB inhibitors rendered chemoresistant cancer cell lines sensitive to chemotherapeutic agent-induced apoptosis [121]. Here, NFKB1 is linked to cancer.