TNFAIP3 and diffuse large B-cell lymphoma: Mutations in genes encoding NF-κB regulators were also found in the activated B-cell-like subtype of diffuse large B-cell lymphomas, including mutations inactivating the NF-κB negative regulator A20/TNFAIP3 and mutations activating the CARD11, TRAF2, TRAF5, TAK1, and RANK positive regulators of NF-κB [32,33,34].