These data, together with findings that NF-κB is constitutively activated in transgenic mouse models of T-ALL induced by Notch1, Notch3, Tal1, and TEL-JAK2 oncoproteins [68,69,70,71], indicate that NF-κB activation occurs frequently in T-ALL leukemic cells. This evidence concerns the gene NOTCH3 and acute lymphoblastic leukemia.