Although the impact of NF-κB inhibition on human T-ALL growth in xenograft mouse models is yet to be investigated, T-cell leukemogenesis in mice engrafted with syngenic bone marrow progenitors transduced with intracellular NOTCH1 protein (ICN1) was shown to be impaired by either T cell-specific expression of an undegradable IκBα mutant (IκBαΔN) protein [67] or hematopoietic lineage deletion of NEMO [71]. This evidence concerns the gene NFKB1 and acute lymphoblastic leukemia.