MUC1 gene expression is regulated by a tightly related combination of DNA methylation and histone modification via histone H3 lysine 9 (H3-K9) in the 5'-flanking region of the MUC1 promoter in cancer cell lines including HPAFII (MUC1+), BxPC3 (MUC1+), PANC1 (MUC1+/–) pancreatic cell lines [67]. Here, MUC1 is linked to cancer.