DPYD and Hand-foot syndrome: In order to test the hypothesis that the occurrence of HFS could be related to tissue-specific expression of drug-metabolizing enzymes in the skin of the palms and soles, Milano et al. measured the expression of dThdPase (activation pathway), DPD (catabolic pathway) and cell proliferation (Ki67) in the skin of the palm (target tissue for HFS) and of the lower back (control area) with punch biopsy specimens [48].