BRCA1 and breast cancer: Such germline mutations lead to a risk of developing breast cancer of 45% at the age of 70 in BRCA1 carrier women and the risk of an ovarian neoplasia of about 40% at age 70, whereas in BRCA2 mutation carriers breast cancer risk is of 35% at age 70 and about 20% of ovarian cancer at age 70 [7].