EGFR and neoplasm: Currently a chimeric human/murine monoclonal anti-EGF-R antibody (Cetuximab) is in clinical use that showed in preclinical studies three different mechanisms affecting tumor cells: (a) enhanced tumor cell apoptosis, inhibition of proliferation and invasiveness by blocking the tyrosine-kinase mediated pathways; (b) antibody-dependant cell mediated toxicity; and (c) blockage of the nuclear import of EGF-R preventing activation of DNA repair.