Furthermore, Gil et al. demonstrated in a recent in vitro model involving DRG and PCa cell lines a major role for GDNF in the neurite-targeted migration of PCa cells: DRG derived from mice deficient in GDNF failed to attract PCa cells, and systemic blockade of the receptor tyrosine kinase RET, which is a downstream target of GNDF, could prevent NI toward the spinal cord and paralysis in mice [44]. This evidence concerns the gene RET and posterior cortical atrophy.