Plasma YKL-40 is elevated in most patients with moderate to severe liver fibrosis and cirrhosis, independently of disease etiology, and may provide new information of ongoing fibrogenesis in the liver [160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178]. This evidence concerns the gene CHI3L1 and Hepatic fibrosis.