Collectively, the ability of Prx-1 to chaperone in elevated oxidative stress conditions and enhance AR transactivation combined with Prx-1 and Txn-1’s role in differentially regulating transcription factor activity suggests that aggressive PCa cells might use antioxidants to facilitate AR mediated signaling and growth during hypoxia and conditions of high oxidative stress. This evidence concerns the gene PRDX1 and posterior cortical atrophy.