SLC6A4 and breast carcinoma: While there might be an increased risk for breast cancer associated with the use of SSRIs, a decreased risk of colorectal cancer was correlated with a high SSRI dose It has been proposed that SERT is a novel target for the anti‐tumor activity of amphetamine analogs; whereas the impact of antidepressants on malignant B cells might be independent of the transporter itself [36].